Discover the Power of Human Keratin

Advancing the Science of Wound Healing

ProgenaMatrix is an active wound matrix manufactured from human keratin and numerous other proteins.

Just below the outer layer of skin is a thin, hydrated layer of keratin called the stratum lucidum. Focusing on this specialized skin layer for our bio-inspired design, we engineered a hydrated keratin wound matrix that is substantially thicker and highly capable of regulating moisture exchange in the wound bed.

Since keratin is a major structural protein in our skin, ProgenaMatrix is naturally biocompatible with dermal wounds of numerous etiologies. ProgenaMatrix may be used under the guidance of a healthcare professional in the management of the following types of dry, light, and moderately exuding partial and full thickness wounds: pressure (stage I-IV) and venous stasis ulcers, ulcers caused by mixed vascular etiologies, diabetic ulcers, donor sites and grafts.

Learn more about ProgenaMatrix™ human keratin wound dressing.

ProgenaMatrix™ Benefits

  • Biocompatible substrate for wound bed interface – from combination of human keratin and associated proteins
  • Maintains structural integrity – non-degrading, does not dissolve in the wound bed
  • Atraumatic dressing change – non-adherent design is easy to remove and replace
  • Wound margin visualization – transparent matrix allows for effortless visualization of wound bed

The Importance of Human Keratin

Until recently, keratin has long been considered to have the singular function of providing structure to cells and tissue. Now, Cell Constructs has identified another important function for human keratin – as an active wound care matrix. It’s estimated that 14 million people suffer from chronic wounds annually. Complications from chronic wounds can lead to debilitating and life-threatening complications as well as increased healthcare costs.1

Recent published evidence suggests that human keratin’s role as a biomaterial may serve even more purposes. As research moves forward, the scientific evidence supporting the benefits of human keratin continues to expand.

1 Armstrong DG, Boulton AJM, Bus SA. Diabetic foot ulcers and their recurrence. N Engl J Med 2017;376:2367-7.

How ProgenaMatrix Works

The unique characteristics of ProgenaMatrix make it a biocompatible primary wound matrix and protective barrier. ProgenaMatrix is engineered to be transparent, allowing for wound visualization during treatment. ProgenaMatrix is packaged fully hydrated and capable of delivering moisture to the wound bed. As healing is induced and wound margins shrink, ProgenaMatrix is designed to lift up and away as tissue heals. By limiting contact with the peri-wound tissue, the risk of maceration diminishes substantially.1

1. Mikel G, Weir D. Prevention and Treatment of Moisture-Associated Skin Damage (Maceration) in the Periwound Skin. Journal of Wound, Ostomy, and Continence Nursing. 2007; 34, 2: 153-157.

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ProgenaMatrix is currently undergoing a 510k premarket review by FDA for dry, light and moderately exuding partial and full thickness wounds. Not available for sale or other clinical use.

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